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Completely, our details supply evidence to the probable of mixing CX-5461 and PARPi for strengthening the procedure of HR-deficient HGSOC. We exhibit that CX-5461 boosts the artificial lethal conversation of PARPi with HRD and clearly demonstrate that CX-5461 has a unique mechanism of motion to PARPi. Importantly, we characterised BRCA-mutated and